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Waiver Wire Targets for Week 1 (2025 Fantasy Football) 

The NFL season is finally here! Drafts are done, rosters are set, and now it’s time to look ahead to fantasy football waiver wire targets for Week 1. This is the first edition of my weekly waiver wire column—where I’ll highlight the best sleepers, breakouts, and must-add players who could help you win your league. 

As the season progresses, I’ll continue to expand this column and add exclusive content to a subscription site (free for this season while I build it out). For now, let’s focus on the most important part of Week 1: finding those under-the-radar waiver wire gems before your league-mates do. 

Waiver Wire Strategy for Week 1 

Before we dive into the player list, let’s talk roster construction: 

These early-season waiver wire stashes can be league-winners—or valuable trade chips down the line. 

Top 5 Waiver Wire Targets – Week 1 

Here are my Top 5 overall fantasy football waiver wire pickups for Week 1

1a. RB Dylan Sampson (28.6% rostered) 
1b. WR Donte Thornton Jr. (5.9% rostered) 
1c. WR Ced Tillman (41.5% rostered) 
4. TE Darren Waller (22.4% rostered) 
5. TE Mason Taylor (6.2% rostered) 

These players have breakout potential and could give you weekly starter-level production—or serve as valuable trade bait later in the season. 

Waiver Wire Pickups by Position 

Quarterbacks 

Running Backs 

Wide Receivers 

Tight Ends 

Defenses (DST) 

Final Thoughts 

Week 1 is the perfect time to take risks on fantasy football sleepers and breakout candidates. Don’t waste valuable roster space on backups who won’t start—use the waiver wire to build depth and find the players who can become difference-makers by midseason. 

Stay tuned each week for updated waiver wire targets, sleepers, and roster strategy tips. Let’s dominate this fantasy football season together. 

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